18:6 Fasting: Pros, Cons, Sample Eating Schedule & Expert Tips

Intermittent fasting (IF), or time-restricted feeding, can yield profound benefits like boosting energy, increasing cognitive function, and reducing inflammation when done properly.

But not all types of fasting are equal. You have your 16:8 schedule, 20:4 schedule, and more—all of which restrict feeding windows differently and have a unique impact on metabolic health. Let's take a closer look at the benefits and risks associated with an 18:6 fasting schedule.

Following a 18:6 fasting schedule means that you fast for 18 hours a day and eat for six hours a day.

"[18:6] is a term used to explain a person's fasting window and eating window," Mindy Pelz, D.C., author of Fast Like a Girl, tells mindbodygreen. "Eighteen hours is the length of time they consistently go without food, and six hours is the time period in which they eat their meals," she says. 

Researchers posit1 that the average American consumes the majority of their caloric intake within a 12-hour feeding window. That makes 18:6 a moderate-to-advanced fasting option—it's more restrictive than 16:8 fasting but not as intense as alternate-day fasting or the 5:2 diet. 

As such, according to Madiha Saeed, M.D., author of The Holistic Rx, the 18:6 IF schedule might be beneficial for someone experiencing a weight loss plateau on the 16:8 schedule.  

The different stages of fasting support an important digestive mechanism called the migrating motor complex (MMC) that controls stomach and small intestinal contractions in a cyclical pattern over a period of about two hours, says Saeed. Spacing out your meals, as you do on an 18:6 fasting schedule, can enhance MMC function5.

Saeed says fasting also stimulates the production of cyclic adenosine monophosphate (c-AMP)6, a crucial messenger that supports gut health.

When we go hours without food, it can increase fat-burning lipolysis, enhance metabolic flexibility, and accelerate your metabolic rate7. Fasting also stimulates pathways that build new mitochondria8 and enhance cellular energy, Saeed says. 

Pelz says after 18 hours in a fasted state, your body will experience a wide array of positive short-term benefits like enhanced mental clarity and cognitive function9.

Fasting is also being researched as a preventive tool against cognitive decline and disorders like dementia10. "Insulin resistance, obesity, and metabolic syndrome are all associated with cognitive decline...and fasting reduces those conditions," Jason Fung, M.D., a nephrologist and intermittent fasting expert, previously told mindbodygreen.

Fasting (especially when paired with a keto eating pattern) can also stimulate ketone production, which has been shown to boost neural metabolism11, giving you more energy and mental clarity, Pelz says.

Saeed says IF, specifically the 18:6 model, activates the Nrf2 gene pathway13 that improves detoxification and stem cell activation. This triggers new cell formation, increases mitochondrial function, and promotes autophagy—the body's natural cleansing process that removes damaged proteins, clears damaged cellular parts, and assists with cellular repair and regeneration.

"Fasting improves the immune system [by] reducing inflammation14 and reduces immunosenescence15—the gradual deterioration of the immune system over time," Saeed shares.

Saeed says you're far more likely to achieve your goal if you write it down and get clear on your "why." "Determine your goals for fasting," she says. "What are you trying to achieve? Weight loss, improved metabolic flexibility, reduced insulin or leptin resistance, resetting your poor eating habits and lifestyle habits, anti-aging, lowering inflammation?"

It's a common misconception that you can still reap the benefits of IF while loading your body with oversize portions of your favorite comfort foods.

"Focus on nutrient-dense foods with protein, healthy fats, plenty of fiber, lots of spices, and eating the rainbow," says Saeed. She recommends avoiding processed foods that contain added sugar, gluten, seed oils, and chemical food additives. Breaking up longer fasts by drinking a cup of broth can also help stave off hunger (though it will technically "break" your fast).

Hunger pangs might be the most distracting bodily mechanism in the world. But if you don't give in to them right away, you'll be promoting your body's fat-burning processes, according to Saeed.

"The prominent hunger hormone ghrelin, which gets your stomach to growl with the secretion of digestive enzymes, spikes for about 20 minutes to compel you to eat," she says. "After that period of time, your body realizes it's not getting food, so the ghrelin spike will subside and you will start to accelerate fat burning and ketone production."

Detoxing may be one of IF's most prized benefits, but it can initially present itself in uncomfortable ways, according to Saeed.

It's not enough to simply fast—the success of IF requires adequate hydration. If you're looking for more excitement than plain water, Saeed says you can also hydrate with plain green and black teas and other teas like ginger and herbal, which are packed with polyphenols and other compounds that stimulate autophagy.  

Keep in mind that when you fast, you run the risk of flushing out electrolytes like sodium, potassium, magnesium, and chloride that impact every cell of your body. "So when fasting, supplementing with electrolytes is important," she says. And, "During your feeding window, make sure to salt your food."

If this all sounds a little daunting, remember Pelz's advice: "Unlike any other diet, fasting gets easier with time, so hang in there!"

It's easy to get confused between the two popular IF modalities, but they impact the body differently. "The only difference is two hours of fasting, [but] when you hit the 18-hour mark, your body will now begin to detox and get rid of aging cells at a quicker rate," says Pelz.

To find out which style is best for you, Saeed says to "See how you feel. Start with 16:8 fasting most days of the week, and from there you can throw in the occasional challenge day where you try to extend beyond the 16-hour mark to spur a boost in metabolic flexibility."

While there's no universal recommendation for the amount of time you can do an 18:6 fast, Saeed says women will want to be extra cautious about fasting length, due to their hormone fluctuations.

"There is no one-size-fits-all plan for women," says Saeed. "It depends on your individual needs, depending on if you're cycling, perimenopausal, or in menopause, as each of these stages in a woman's life requires a unique approach to fasting and nutrition."

If you're age 35 or under, Saeed recommends a more flexible fasting schedule, such as every other day or for a few days a week, and to avoid fasting if you plan on becoming pregnant or are pregnant. Read this guide to intermittent fasting for women for more information.

You may also experience digestive issues, "as it may be difficult to fit all your nutritional needs in a smaller window," says Saeed. Pelz warns some people might experience detox reactions with flu-like symptoms, constipation, skin rashes, brain fog, or even gain weight.

Saeed says IF can create nutrient deficiencies or trigger hypoglycemia that may impact and disrupt the production of reproductive hormones. She says if you're unable to regulate your blood sugar, it's a sign that IF may not be the right strategy for you. 

"I have women start with protein and healthy fats at each meal, and once their blood sugar is better stabilized, they can start fasting," she says. While IF during menopause and perimenopause can be beneficial, she says it's crucial to pay extra attention to getting proper sleep, managing stress, and getting proper nutrition. 

Other populations who should stay away from 18:6 fasting include children and teens under age 18; pregnant women; those who are breastfeeding or trying to conceive; those being treated for serious kidney, cardiovascular, lung, or liver issues; those with disordered eating or eating disorders; and those who are underweight. Competing female athletes, those who have undergone recent hospitalization, those struggling with alcohol use, and anyone experiencing significant or prolonged stress should also avoid fasting.